Article
Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste.
The Journal of biological chemistry - 15 Apr 2005
Jiang Peihua, Cui Meng, Zhao Baohua, Liu Zhan, Snyder Lenore A, Benard Lumie M J, Osman Roman, Margolskee Robert F, Max Marianna
Abstract excerpt
The detection of sweet-tasting compounds is mediated in large part by a heterodimeric receptor comprised of T1R2+T1R3. Lactisole, a broad-acting sweet antagonist, suppresses the sweet taste of sugars, protein sweeteners, and artificial sweeteners. Lactisole's inhibitory effect is specific to humans and other primates; lactisole does not affect responses to sweet compounds in rodents. By heterologously expressing...
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