Article
Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners.
Human molecular genetics - 1 Sept 2011
Roudnitzky Natacha, Bufe Bernd, Thalmann Sophie, Kuhn Christina, Gunn Howard C, Xing Chao, Crider Bill P, Behrens Maik, Meyerhof Wolfgang, Wooding Stephen P
Abstract excerpt
Bitter taste perception is initiated by TAS2R receptors, which respond to agonists by triggering depolarization of taste bud cells. Mutations in TAS2Rs are known to affect taste phenotypes by altering receptor function. Evidence that TAS2Rs overlap in ligand specificity suggests that they may also contribute joint effects. To explore this aspect of gustation, we examined bitter perception of saccharin and...
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