Article

Sensitivity of human sweet taste receptor subunits T1R2 and T1R3 to activation by glucose enantiomers

2022-12-19

Abstract excerpt

We have previously shown that L-glucose, the non-caloric enantiomer of D-glucose, activates the human sweet taste receptor T1R2/T1R3 transiently expressed in HEK293T cells. Here we show that D- and L-glucose can also activate T1R2 and T1R3 expressed without the counterpart monomer. Serine mutation to alanine in residue 147 in the binding site of T1R3 VFT domain, completely abolishes T1R3S147A activation by either...

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Literature Corpus work: 95a23622-5e3c-512b-88e3-471bafb1003c
DOI: 10.1101/2022.12.19.520966

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Sensitivity of human sweet taste receptor subunits T1R2 and T1R3 to activation by glucose enantiomersDOI 10.1101/2022.12.19.520966Read

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