Article
High frequency of p53 mutations in ultraviolet radiation-induced murine skin tumors: evidence for strand bias and tumor heterogeneity.
Cancer research - 1 Jul 1993
Kanjilal S, Pierceall W E, Cummings K K, Kripke M L, Ananthaswamy H N
Abstract excerpt
Exposure to UV radiation has long been associated with the development of skin cancers. To identify the molecular targets in UV carcinogenesis, we analyzed 11 UV-induced murine skin cancers for mutations in the p53 tumor suppressor gene and found a 100% incidence rate. Such a high frequency of p5...
Topics
- Alleles
- Animals
- Base Sequence
- DNA Damage
- DNA, Neoplasm
- Female
- Genes, p53
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Neoplasms, Radiation-Induced