Analysis of the tumor suppressor gene p53 in xeroderma pigmentosum fibroblasts.

doi:10.1016/0304-3835(94)90232-1

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Article

Analysis of the tumor suppressor gene p53 in xeroderma pigmentosum fibroblasts.

Cancer letters - 30 Sept 1994

Lavu S, Srivastava M, Srivastava S K

Abstract excerpt

Genetic risk factor(s) for skin cancers have been described in patients with xeroderma pigmentosum (XP). The tumor suppressor gene, p53, is one of the most frequently mutated genes found in human tumors. To evaluate the role of XP-related genetic defects in the p53 gene, skin fibroblast cell line...

Topics

Base Sequence
Cell Line
DNA
DNA Damage
DNA Repair
Exons
Fibroblasts
Genes, p53
Humans
Molecular Sequence Data
Mutation
Neoplasms, Radiation-Induced
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Skin
Skin Diseases
Skin Neoplasms
Ultraviolet Rays

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