Article
Ultraviolet-specific mutations in p53 gene in skin tumors in xeroderma pigmentosum patients.
Cancer research - 1 Jul 1993
Sato M, Nishigori C, Zghal M, Yagi T, Takebe H
Abstract excerpt
Mutations in the p53 gene were identified in five of eight non-melanoma skin tumors in the sun-exposed areas of xeroderma pigmentosum patients by the polymerase chain reaction and single strand conformation polymorphism analysis followed by sequencing of the DNA. All mutations occurred at the dipyrimidine sites, indicating that they were caused by UV irradiation. Two tumors had multiple mutations, and four tumors...
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