Article
Ultraviolet-specific mutations in p53 gene in skin tumors in xeroderma pigmentosum patients.
Cancer research - 1 Jul 1993
Sato M, Nishigori C, Zghal M, Yagi T, Takebe H
Abstract excerpt
Mutations in the p53 gene were identified in five of eight non-melanoma skin tumors in the sun-exposed areas of xeroderma pigmentosum patients by the polymerase chain reaction and single strand conformation polymorphism analysis followed by sequencing of the DNA. All mutations occurred at the dip...
Topics
- Adolescent
- Adult
- Base Sequence
- Carcinoma, Basal Cell
- Carcinoma, Squamous Cell
- Child
- Codon
- DNA, Neoplasm
- DNA, Single-Stranded
- Exons
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Neoplasms, Radiation-Induced
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Skin Neoplasms