Article
Therapeutic vaccination reduces HIV sequence variability.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2008
Hoffmann Dieter, Seebach Judith, Cosma Antonio, Goebel Frank D, Strimmer Korbinian, Schätzl Hermann M, Erfle Volker
Abstract excerpt
With HIV persisting lifelong in infected persons, therapeutic vaccination is a novel alternative concept to control virus replication. Even though CD8 and CD4 cell responses to such immunizations have been demonstrated, their effects on virus replication are still unclear. In view of this fact, we studied the impact of a therapeutic vaccination with HIV nef delivered by a recombinant modified vaccinia Ankara...
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