Article
Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication.
PloS one - 2 Jul 2010
Tarosso Leandro F, Sauer Mariana M, Sanabani Sabri, Giret Maria Teresa, Tomiyama Helena I, Sidney John, Piaskowski Shari M, Diaz Ricardo S, Sabino Ester C, Sette Alessandro, Kalil-Filho Jorge, Watkins David I, Kallas Esper G
Abstract excerpt
BACKGROUND: HIV-1-infected individuals who spontaneously control viral replication represent an example of successful containment of the AIDS virus. Understanding the anti-viral immune responses in these individuals may help in vaccine design. However, immune responses against HIV-1 are normally analyzed using HIV-1 consensus B 15-mers that overlap by 11 amino acids. Unfortunately, this method may underestimate...
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