Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy.

doi:10.1128/JVI.00570-09

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Article

Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy.

Journal of virology - 1 Oct 2009

Shiu Carlum, Cunningham Coleen K, Greenough Thomas, Muresan Petronella, Sanchez-Merino Victor, Carey Vincent, Jackson J Brooks, Ziemniak Carrie, Fox Lawrence, Belzer Marvin, Ray Stuart C, Luzuriaga Katherine, Persaud Deborah

Abstract excerpt

In most human immunodeficiency virus type 1 (HIV-1)-infected individuals who achieve viral loads of <50 copies/ml during highly active antiretroviral therapy (HAART), low levels of plasma virus remain detectable for years by ultrasensitive methods. The relative contributions of ongoing virus replication and virus production from HIV-1 reservoirs to persistent low-level viremia during HAART remain controversial....

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PMID: 19605490
DOI: 10.1128/JVI.00570-09
PMCID: PMC2748010

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