Naturally occurring mutations within HIV-1 V3 genomic RNA lead to antigenic variation dependent on a single amino acid substitution.

doi:10.1016/0042-6822(91)90767-6

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Article

Naturally occurring mutations within HIV-1 V3 genomic RNA lead to antigenic variation dependent on a single amino acid substitution.

Virology - 1 Nov 1991

Wolfs T F, Zwart G, Bakker M, Valk M, Kuiken C L, Goudsmit J

Abstract excerpt

In a study on the evolution of genomic diversity of HIV-1, genomic RNA was isolated from serum of two individuals. Starting at the time of primary infection we collected six samples of serum from each patient over a period of 5 years. Ninety-four cDNA clones (50 of patient 1 and 44 of patient 495) of part of the envelope coding region including the principal neutralization domain (PND) were sequenced. Around the...

Topics

Acquired Immunodeficiency Syndrome
Amino Acid Sequence
Antibody Formation
Antigenic Variation
Base Sequence
Cloning, Molecular
Enzyme-Linked Immunosorbent Assay
Female
Genes, Viral
HIV-1
Homosexuality

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunoglobulin G

Leukemia Virus, Bovine

Molecular Sequence Data

Mutation

Oligodeoxyribonucleotides

Peptides

Source

Open in PubMed

Identifiers

PMID: 1656585
DOI: 10.1016/0042-6822(91)90767-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1656585-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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