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Article

Genetic variation in a human immunodeficiency virus type 2 live-virus Macaca nemestrina vaccine model.

Journal of virology - 1 Oct 1998

Radaelli A, Kraus G, Schmidt A, Badel P, McClure J, Hu S L, Morton W, De Giuli Morghen C, Wong-Staal F, Looney D

Abstract excerpt

Four pigtailed macaques were inoculated with an infectious, apathogenic human immunodeficiency virus type 2 (HIV-2) molecular clone (HIV-2KR) and subsequently challenged with a highly pathogenic strain, HIV-2287, together with two naive control animals. After challenge, two animals inoculated with a high dose of the immunizing strain were protected from CD4 decline and immunodeficiency. To examine the role of...

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Identifiers

PMID: 9733824
DOI: 10.1128/JVI.72.10.7871-7884.1998
PMCID: PMC110110

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