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Article

Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences.

Leukemia - 1 Jan 2008

van Grotel M, Meijerink J P P, van Wering E R, Langerak A W, Beverloo H B, Buijs-Gladdines J G C A M, Burger N B, Passier M, van Lieshout E M, Kamps W A, Veerman A J P, van Noesel M M, Pieters R

Abstract excerpt

Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is characterized by chromosomal rearrangements possibly enforcing arrest at specific development stages. We studied the relationship between molecular-cytogenetic abnormalities and T-cell development stage to investigate whether arrest at specific stages can explain the prognostic significance of specific abnormalities. We extensively studied 72 pediatric...

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Share to Basic Helix-Loop-Helix Transcription Factors
Share to Leukemia-Lymphoma, Adult T-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Fusion

Share to Receptor, Notch1

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Receptors, Antigen, T-Cell, gamma-delta

Share to RNA, Neoplasm

Share to T-Cell Acute Lymphocytic Leukemia Protein 1

Source

Identifiers

PMID: 17928886
DOI: 10.1038/sj.leu.2404957

Genes

TAL1
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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