Article
T cell receptor genotyping and HOXA/TLX1 expression define three T lymphoblastic lymphoma subsets which might affect clinical outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2008
Baleydier Frederic, Decouvelaere Anne-Valerie, Bergeron Julie, Gaulard Philippe, Canioni Danielle, Bertrand Yves, Lepretre Stephane, Petit Barbara, Dombret Herve, Beldjord Kheira, Molina Thierry, Asnafi Vahid, Macintyre Elizabeth
Abstract excerpt
PURPOSE: T lymphoblastic lymphomas (T-LBL) are rare disorders of immature T cells which predominantly involve the mediastinum. Their oncogenic pathways and prognostic variables are not clear. EXPERIMENTAL DESIGN: We undertook a retrospective study of 41 cytoplasmic CD3+ T-LBL (nine cases aged <16 years) by assessing stage of maturation arrest based on T cell receptor (TCR) immunogenotyping, immunohistochemistry,...
Topics
- Adolescent
- Adult
- Aged
- Biopsy
- Child
- Child, Preschool
- DNA, Neoplasm
- Female
- Genotype
- Homeodomain Proteins