Article
Analysis of TCR, pT alpha, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment.
Blood - 1 Apr 2003
Asnafi Vahid, Beldjord Kheira, Boulanger Emmanuelle, Comba Béatrice, Le Tutour Patricia, Estienne Marie-Hélène, Davi Frédéric, Landman-Parker Judith, Quartier Pierre, Buzyn Agnès, Delabesse Eric, Valensi Françoise, Macintyre Elizabeth
Abstract excerpt
T-acute lymphoblastic leukemias (T-ALLs) derive from human T-lymphoid precursors arrested at various early stages of development. Correlation of phenotype and T-cell receptor (TCR) status with RAG-1 and pT alpha transcription in 114 T-ALLs demonstrated that they largely reflect physiologic T-lymphoid development. Half the TCR alpha beta lineage T-ALLs expressed a pre-TCR, as evidenced by RAG-1, pT alpha, and cTCR...
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