Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HOX gene expression in phenotypic and genotypic subgroups and low HOXA gene expression as an adverse prognostic factor in pediatric ALL.

Pediatric blood & cancer - 1 Dec 2010

Starkova Julia, Zamostna Blanka, Mejstrikova Ester, Krejci Roman, Drabkin Harry A, Trka Jan

Abstract excerpt

BACKGROUND: HOX genes play an important role in both normal lymphopoiesis and leukemogenesis. However, HOX expression patterns in leukemia cells compared to normal lymphoid progenitors have not been systematically studied in acute lymphoblastic leukemia (ALL) subtypes. PROCEDURE: The RNA expression levels of HOXA, HOXB, and CDX1/2 genes were analyzed by qRT-PCR in a cohort of 61 diagnostic pediatric ALL samples...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Promoter Regions, Genetic
Share to CDX2 Transcription Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Expression Regulation, Leukemic

Share to Homeodomain Proteins

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Prognosis

Share to Transcription Factors

Source

Identifiers

PMID: 20672366
DOI: 10.1002/pbc.22749

Genes

HOXA7
BCR
CDX2
CDX1
HOXA13
HOXA3
HOXB2
HOXB3
HOXB6
HOXB7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HOX gene expression in phenotypic and genotypic subgroups and low HOXA gene expression as an adverse prognostic factor in pediatric ALL.PMID 20672366Read ↗

HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL)Semantic proximity Read ↗

The Role of the HOXA Gene Family in Acute Myeloid LeukemiaSemantic proximity Read ↗

Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemiaSemantic proximity Read ↗

Hox expression in AML identifies a distinct subset of patients with intermediate cytogeneticsSemantic proximity Read ↗

An early thymic precursor phenotype predicts outcome exclusively in HOXA-overexpressing adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.Semantic proximity Read ↗

Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia.Semantic proximity Read ↗

Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cellsSemantic proximity Read ↗

Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patientsSemantic proximity Read ↗

Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences.Semantic proximity Read ↗

The role of HOX genes in malignant myeloid diseaseSemantic proximity Read ↗

HOX expression patterns identify a common signature for favorable AML.Semantic proximity Read ↗

The transcriptome of the leukemogenic homeoprotein HOXA9 in human hematopoietic cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.