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BCL11B, FLT3, NOTCH1 and FBXW7 mutation status in T-cell acute lymphoblastic leukemia patients.

Blood cells, molecules & diseases - 1 Jan 2013

Kraszewska Monika D, Dawidowska Małgorzata, Kosmalska Maria, Sędek Lukasz, Grzeszczak Władysław, Kowalczyk Jerzy R, Szczepański Tomasz, Witt Michał

Abstract excerpt

T-cell acute lymphoblastic leukemia is a heterogeneous malignancy originating from developing lymphocyte precursors likely due to mutations in genes regulating thymocyte differentiation. Here, we characterized mutation status of BCL11B and FLT3 genes, presumably involved in T-ALL, together with FBXW7 and NOTCH1 as known players in T-ALL in 65 pediatric T-cell acute lymphoblastic leukemia patients. We also aimed...

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Identifiers

PMID: 23040356
DOI: 10.1016/j.bcmd.2012.09.001

Genes

NOTCH1
FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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