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Article

Age-related phenotypic and oncogenic differences in T-cell acute lymphoblastic leukemias may reflect thymic atrophy.

Blood - 15 Dec 2004

Asnafi Vahid, Beldjord Kheira, Libura Marta, Villarese Patrick, Millien Corrine, Ballerini Paola, Kuhlein Emilienne, Lafage-Pochitaloff Marina, Delabesse Eric, Bernard Olivier, Macintyre Elizabeth

Abstract excerpt

Postnatal thymic involution occurs progressively throughout the first 3 decades of life. It predominantly affects T-cell receptor (TCR) alphabeta-lineage precursors, with a consequent proportional increase in multipotent thymic precursors. We show that T-acute lymphoblastic leukemias (T-ALLs) dem...

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Source

Identifiers

PMID: 15054041
DOI: 10.1182/blood-2003-11-3944

Genes

TAL1
LMO1
LMO2
LYL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15054041-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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