Article
Genetic contribution of major histocompatibility complex class II region to type 1 autoimmune hepatitis susceptibility in Venezuela.
Liver international : official journal of the International Association for the Study of the Liver - 1 Dec 2007
Fortes María del Pilar, Machado Irma V, Gil Gisselle, Fernández-Mestre Mercedes, Dagher Lucy, León Roberto V, Bianco Nicolás E, Tassinari Paolo
Abstract excerpt
AIMS: Autoimmune hepatitis (AIH) is a progressive liver disease characterized by the presence of circulating autoantibodies, hypergammaglobulinaemia and a favourable response to immunosuppressive treatment. Although the pathogenesis of type 1 AIH is unknown, disease susceptibility is partially determined by genes linked to the class II region of the major histocompatibility complex. Type 1 AIH has been associated...
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