Article
Pediatric and adult forms of type I autoimmune hepatitis in Argentina: evidence for differential genetic predisposition.
Hepatology (Baltimore, Md.) - 1 Dec 1999
Pando M, Larriba J, Fernandez G C, Fainboim H, Ciocca M, Ramonet M, Badia I, Daruich J, Findor J, Tanno H, Cañero-Velasco C, Fainboim L
Abstract excerpt
The aim of this study was to compare major histocompatibility complex (MHC) class II susceptibility to type 1 autoimmune hepatitis (AH) between children and adults of the same ethnic group. HLA-DRB1, HLA-DRB3, HLA-DQA1, and HLA-DQB1 gene subtypes were examined by high resolution oligonucleotide typing in 122 pediatric (PAH) and 84 adult (AAH) patients and in 208 controls. In children, HLA-DRB1*1301 was the...
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