Article
HLA-DRB1*03:01 and HLA-DRB1*04:01 modify the presentation and outcome in autoimmune hepatitis type-1.
Genes and immunity - 1 Jun 2015
van Gerven N M F, de Boer Y S, Zwiers A, Verwer B J, Drenth J P H, van Hoek B, van Erpecum K J, Beuers U, van Buuren H R, den Ouden J W, Verdonk R C, Koek G H, Brouwer J T, Guichelaar M M J, Vrolijk J M, Coenraad M J, Kraal G, Mulder C J J, van Nieuwkerk C M J, Bloemena E, Verspaget H W, Kumar V, Zhernakova A, Wijmenga C, Franke L, Bouma G
Abstract excerpt
The classical human leukocyte antigen (HLA)-DRB1*03:01 and HLA-DRB1*04:01 alleles are established autoimmune hepatitis (AIH) risk alleles. To study the immune-modifying effect of these alleles, we imputed the genotypes from genome-wide association data in 649 Dutch AIH type-1 patients. We therefore compared the international AIH group (IAIHG) diagnostic scores as well as the underlying clinical characteristics...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.