Article
Naturally occurring short splice variant of CYLD positively regulates dendritic cell function.
Blood - 4 Jun 2009
Srokowski Cathy Cecilia, Masri Joumana, Hövelmeyer Nadine, Krembel Anna Katharina, Tertilt Christine, Strand Dennis, Mahnke Karsten, Massoumi Ramin, Waisman Ari, Schild Hansjörg
Abstract excerpt
Deubiquitination of NF-kappaB members by CYLD is crucial in controlling the magnitude and nature of cell activation. The role of the naturally occurring CYLD splice variant in dendritic cell (DC) function was analyzed using CYLD(ex7/8) mice, which lack the full-length CYLD (flCYLD) transcript and overexpress the short splice variant (sCYLD). Bone marrow-derived DCs from CYLD(ex7/8) mice display a hyperactive...
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