Article
Mutated cylindromatosis gene affects the functional state of dendritic cells.
European journal of immunology - 1 Oct 2010
Bros Matthias, Dexheimer Nadine, Besche Verena, Masri Joumana, Trojandt Stefanie, Hövelmeyer Nadine, Reissig Sonja, Massoumi Ramin, Grabbe Stephan, Waisman Ari, Reske-Kunz Angelika B
Abstract excerpt
Cylindromatosis gene (CYLD) is a ubiquitously expressed deubiquitinating enzyme, which interacts with members of the NF-κB signaling pathway and attenuates NF-κB and JNK signaling. Here, we report that DC derived from transgenic mice, which solely express a naturally occurring CYLD isoform (CYLD(ex7/8)), display a higher content of nuclear RelB and express elevated levels of NF-κB family members as well as of...
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