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Article

Regulation of natural killer T-cell development by deubiquitinase CYLD.

The EMBO journal - 5 May 2010

Lee Andrew J, Zhou Xiaofei, Chang Mikyoung, Hunzeker John, Bonneau Robert H, Zhou Dapeng, Sun Shao-Cong

Abstract excerpt

Natural killer T (NKT) cells modulate immune responses against pathogens and tumours, as well as immunological tolerance. We show here that CYLD, a tumour suppressor with deubiquitinase function, has a pivotal and cell-intrinsic function in NKT cell development. Unlike other known NKT regulators,...

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Topics

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Share to Antigens, Differentiation, T-Lymphocyte
Share to Cysteine Endopeptidases
Share to Deubiquitinating Enzyme CYLD

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inducible T-Cell Co-Stimulator Protein

Share to Interleukin-7

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Source

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Identifiers

PMID: 20224552
DOI: 10.1038/emboj.2010.31
PMCID: PMC2876956

Genes

CYLD
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-20224552-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Regulation of natural killer T-cell development by deubiquitinase CYLD.PMID 20224552Read ↗

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The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.Semantic proximity Read ↗

CYLD-Mediated Signaling and DiseasesSemantic proximity Read ↗

Deubiquitinating activity of CYLD is impaired by SUMOylation in neuroblastoma cells.Semantic proximity Read ↗

Naturally occurring short splice variant of CYLD positively regulates dendritic cell function.Semantic proximity Read ↗

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.Semantic proximity Read ↗

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Truncation of the Catalytic Domain of the Cylindromatosis Tumor Suppressor Impairs Lung MaturationSemantic proximity Read ↗

NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway.Semantic proximity Read ↗

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