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Article

Regulation of natural killer T-cell development by deubiquitinase CYLD.

The EMBO journal - 5 May 2010

Lee Andrew J, Zhou Xiaofei, Chang Mikyoung, Hunzeker John, Bonneau Robert H, Zhou Dapeng, Sun Shao-Cong

Abstract excerpt

Natural killer T (NKT) cells modulate immune responses against pathogens and tumours, as well as immunological tolerance. We show here that CYLD, a tumour suppressor with deubiquitinase function, has a pivotal and cell-intrinsic function in NKT cell development. Unlike other known NKT regulators, CYLD is dispensable for intrathymic NKT cell maturation but is obligatory for the survival of immature NKT cells....

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Topics

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Share to Antigens, Differentiation, T-Lymphocyte
Share to Cysteine Endopeptidases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Deubiquitinating Enzyme CYLD

Share to Inducible T-Cell Co-Stimulator Protein

Share to Interleukin-7

Share to Lymphopoiesis

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Share to Receptors, Interleukin-7

Source

Open in PubMed Open full text

Identifiers

PMID: 20224552
DOI: 10.1038/emboj.2010.31
PMCID: PMC2876956

Genes

CYLD
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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