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Article

PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes.

PloS one - 1 Jan 2013

Thuille Nikolaus, Wachowicz Katarzyna, Hermann-Kleiter Natascha, Kaminski Sandra, Fresser Friedrich, Lutz-Nicoladoni Christina, Leitges Michael, Thome Margot, Massoumi Ramin, Baier Gottfried

Abstract excerpt

In T cells PKCθ mediates the activation of critical signals downstream of TCR/CD28 stimulation. We investigated the molecular mechanisms by which PKCθ regulates NFκB transactivation by examining PKCθ/β single and double knockout mice and observed a redundant involvement of PKCθ and PKCβ in this signaling pathway. Mechanistically, we define a PKCθ-CYLD protein complex and an interaction between the positive PKCθ/β...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23335970
DOI: 10.1371/journal.pone.0053709
PMCID: PMC3546006

Genes

CYLD
MALT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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