Article
The deubiquitinating enzyme CYLD regulates the differentiation and maturation of thymic medullary epithelial cells.
Immunology and cell biology - 1 Jul 2015
Reissig Sonja, Hövelmeyer Nadine, Tang Yilang, Weih Debra, Nikolaev Alexey, Riemann Marc, Weih Falk, Waisman Ari
Abstract excerpt
The cross talk between thymocytes and the thymic epithelium is critical for T-cell development and the establishment of central tolerance. Medullary thymic epithelial cells (mTECs) are located in the thymic medulla and mediate the elimination of self-reactive thymocytes, thereby preventing the onset of autoimmunity. Previous studies identified the deubiquitinating enzyme CYLD as a critical regulator of T-cell...
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