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Article

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling.

The EMBO journal - 17 Feb 1997

Iafrate A J, Bronson S, Skowronski J

Abstract excerpt

The Nef protein alters T cell receptor (TCR) signaling in T cells and is critical for the pathogenesis of AIDS. We used a transient expression assay in a human CD4+ T cell line to analyze the interaction of Nef with the TCR machinery. We show that, in addition to down-regulating CD4 expression on the cell surface, Nef blocks a receptor-proximal event in CD3 signaling. Analysis of a large number of mutant Nef...

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Identifiers

PMID: 9049297
DOI: 10.1093/emboj/16.4.673
PMCID: PMC1169669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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