Article

Synergy and allostery in ligand binding by HIV-1 Nef

2020-11-05

Abstract excerpt

The Nef protein of human and simian immunodeficiency viruses (HIV and SIV, respectively) boosts viral pathogenicity through its interactions with host cell proteins. Nef has a folded core domain and large flexible regions, each carrying several protein interaction sites. By combining the polyvalency intrinsic to unstructured regions with the binding selectivity and strength of a 3D folded domain, Nef can bind to m...

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Literature Corpus work: 919ebfb3-4646-5265-bc87-ba77f9f8b6c4
DOI: 10.1101/2020.11.05.369645

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