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Article

Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1

19 Dec 2005

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) pathogenicity factor Nef increases viral replication in vivo. In immortalized cell lines, Nef affects the cell surface levels of multiple receptors and signal transduction pathways. Resting CD4+ T lymphocytes are important targets for HIV-1 infection in vivo-they actively transcribe and express HIV-1 genes and contribute to the local viral burden and long-lived...

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Identifiers

PMID: 16365153
DOI: 10.1189/jlb.0805461

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Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1PMID 16365153Read ↗

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Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta.Semantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Nef Functions at the Level of Virus Entry by Enhancing Cytoplasmic Delivery of VirionsSemantic proximity Read ↗

CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4 + T-Cell Depletion in Human Lymphoid Tissue Ex VivoSemantic proximity Read ↗

Interactions of HIV-1 NEF with cellular signal transducing proteinsSemantic proximity Read ↗

Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1Semantic proximity Read ↗

Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2Semantic proximity Read ↗

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