Article
Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix.
Retrovirology - 31 May 2012
Kuo Lillian S, Baugh Laura L, Denial Sarah J, Watkins Richard L, Liu Mingjie, Garcia J Victor, Foster John L
Abstract excerpt
BACKGROUND: HIV-1 Nef is a multifunctional protein required for full pathogenicity of the virus. As Nef has no known enzymatic activity, it necessarily functions through protein-protein interaction interfaces. A critical Nef protein interaction interface is centered on its polyproline segment (P69VRPQVPLRP78) which contains the helical SH3 domain binding protein motif, PXXPXR. We hypothesized that any Nef-SH3...
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