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Article

Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.

PloS one - 1 Jan 2012

Narute Purushottam S, Smithgall Thomas E

Abstract excerpt

The HIV-1 accessory factor Nef is essential for high-titer viral replication and AIDS progression. Nef function requires interaction with many host cell proteins, including specific members of the Src kinase family. Here we explored whether Src-family kinase activation is a conserved property of Nef alleles from a wide range of primary HIV-1 isolates and their sensitivity to selective pharmacological inhibitors....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to nef Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 22393415
DOI: 10.1371/journal.pone.0032561
PMCID: PMC3290594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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