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Article

Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.

Cancer treatment and research - 1 Jan 2010

Engel Michael E, Hiebert Scott W

Abstract excerpt

The existence of non-random mutations in critical regulators of cell growth and differentiation is a recurring theme in cancer pathogenesis and provides the basis for our modern, molecular approach to the study and treatment of malignant diseases. Nowhere is this more true than in the study of leukemogenesis, where research has converged upon a critical group of genes involved in hematopoietic stem and progenitor...

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Topics

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Share to Cell Transformation, Neoplastic
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Hematopoiesis

Share to Leukemia, Myeloid, Acute

Share to Neoplasm Proteins

Share to Oncogene Proteins, Fusion

Share to Translocation, Genetic

Source

Identifiers

PMID: 20306249
DOI: 10.1007/978-0-387-69259-3_8

Genes

RUNX1

Provenance

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