Article
Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.
Blood - 8 Dec 2011
Bluteau Dominique, Gilles Laure, Hilpert Morgane, Antony-Debré Iléana, James Chloe, Debili Najet, Camara-Clayette Valerie, Wagner-Ballon Orianne, Cordette-Lagarde Veronique, Robert Thomas, Ripoche Hugues, Gonin Patrick, Swierczek Sabina, Prchal Josef, Vainchenker William, Favier Remi, Raslova Hana
Abstract excerpt
RUNX1 encodes a DNA-binding α subunit of the core-binding factor, a heterodimeric transcription factor. RUNX1 is a master regulatory gene in hematopoiesis and its disruption is one of the most common aberrations in acute leukemia. Inactivating or dominant-negative mutations in the RUNX1 gene have been also identified in pedigrees of familial platelet disorders with a variable propensity to develop acute myeloid...
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