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Article

Role of RUNX1 in hematological malignancies

8 Feb 2017

Abstract excerpt

Abstract RUNX1 is a member of the core-binding factor family of transcription factors and is indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations in RUNX1 cause familial platelet disorder with associated myeloid malignancies. Somatic mutations and chromosomal rearrangements...

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Identifiers

PMID: 28179279
DOI: 10.1182/blood-2016-10-687830

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