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Cell cycle corruption in a pre-leukemic ETV6-RUNX1 model exposes RUNX1 addiction as a therapeutic target in acute lymphoblastic leukemia

2020-12-22

Abstract excerpt

<h4>Summary</h4> The ETV6-RUNX1 onco-fusion arises in utero , initiating a clinically silent pre-leukemic state associated with the development of pediatric B-acute lymphoblastic leukemia (B-ALL). We characterize the ETV6-RUNX1 regulome by integrating chromatin immunoprecipitation- and RNA-sequencing and show that ETV6-RUNX1 functions primarily through competition for RUNX1 binding sites and transcriptional repr...

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Identifiers and source

Literature Corpus work
8a44385f-f65d-5f53-97a9-883e82842566
DOI
10.1101/2020.12.22.423823
Open publication

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Cell cycle corruption in a pre-leukemic ETV6-RUNX1 model exposes RUNX1 addiction as a therapeutic target in acute lymphoblastic leukemiaDOI 10.1101/2020.12.22.423823
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