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Leukemic stem cells hijack lineage inappropriate signalling pathways to promote their growth

2023-03-12

Abstract excerpt

<h4>Summary</h4> Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to individual mutations, maintaining a rapidly proliferating blast cell population with fatal consequences for the patient if not treated. The most common treatment option is still chemotherapy which targets such cells....

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Literature Corpus work
05d5558a-d377-553e-aac8-1662108417e2
DOI
10.1101/2023.03.10.532081
Open publication

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Leukemic stem cells hijack lineage inappropriate signalling pathways to promote their growthDOI 10.1101/2023.03.10.532081
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