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Article

Closing in on the resting state of the Shaker K(+) channel.

Neuron - 4 Oct 2007

Pathak Medha M, Yarov-Yarovoy Vladimir, Agarwal Gautam, Roux Benoît, Barth Patrick, Kohout Susy, Tombola Francesco, Isacoff Ehud Y

Abstract excerpt

Membrane depolarization causes voltage-gated ion channels to transition from a resting/closed conformation to an activated/open conformation. We used voltage-clamp fluorometry to measure protein motion at specific regions of the Shaker Kv channel. This enabled us to construct new structural models of the resting/closed and activated/open states based on the Kv1.2 crystal structure using the Rosetta-Membrane...

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Identifiers

PMID: 17920020
DOI: 10.1016/j.neuron.2007.09.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Closing in on the resting state of the Shaker K(+) channel.PMID 17920020Read ↗

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Initial steps in the opening of a Shaker potassium channel.Semantic proximity Read ↗

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Closed state structure of the pore revealed by uncoupled Shaker K+ channel.Semantic proximity Read ↗

The orientation and molecular movement of a k(+) channel voltage-sensing domain.Semantic proximity Read ↗

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A characterization of the activating structural rearrangements in voltage-dependent Shaker K+ channels.Semantic proximity Read ↗

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