Closing in on the resting state of the Shaker K(+) channel.

doi:10.1016/j.neuron.2007.09.023

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Article

Closing in on the resting state of the Shaker K(+) channel.

Neuron - 4 Oct 2007

Pathak Medha M, Yarov-Yarovoy Vladimir, Agarwal Gautam, Roux Benoît, Barth Patrick, Kohout Susy, Tombola Francesco, Isacoff Ehud Y

Abstract excerpt

Membrane depolarization causes voltage-gated ion channels to transition from a resting/closed conformation to an activated/open conformation. We used voltage-clamp fluorometry to measure protein motion at specific regions of the Shaker Kv channel. This enabled us to construct new structural models of the resting/closed and activated/open states based on the Kv1.2 crystal structure using the Rosetta-Membrane...

Topics

Animals
Dose-Response Relationship, Radiation
Electric Stimulation
Ion Channel Gating
Membrane Potentials
Models, Biological
Models, Molecular
Mutation
Oocytes
Patch-Clamp Techniques
Protein Conformation
Protein Structure, Tertiary
Shaker Superfamily of Potassium Channels

Source

Open in PubMed

Identifiers

PMID: 17920020
DOI: 10.1016/j.neuron.2007.09.023

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