Article

Retinoic acid generates a beneficial microenvironment for liver progenitor cell activation in acute liver failure

2024-01-24

Abstract excerpt

<h4>Objective</h4> When massive necrosis occurs in acute liver failure (ALF), rapid expansion of hepatic stem cells called liver progenitor cells (LPC) in a process called ductular reaction (DR) is required for survival. The exact underlying mechanisms of this process are not known to date. In ALF, high levels of retinoic acid (RA), a molecule known for its pleiotropic roles in embryonic development, are secreted...

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Literature Corpus work: ceee7a97-6cd9-5d21-9b0f-05d10f160cb1
DOI: 10.1101/2024.01.23.576749

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