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Article

Beta-carotene storage, conversion to retinoic acid, and induction of the lipocyte phenotype in hepatic stellate cells.

Journal of cellular biochemistry - 15 May 2004

Martucci Renata B, Ziulkoski Ana L, Fortuna Vitor A, Guaragna Regina M, Guma Fátima C R, Trugo Luiz C, Borojevic Radovan

Abstract excerpt

Hepatic stellate cells (HSCs) are the major site of retinol (ROH) metabolism and storage. GRX is a permanent murine myofibroblastic cell line, derived from HSCs, which can be induced to display the fat-storing phenotype by treatment with retinoids. Little is known about hepatic or serum homeostasis of beta-carotene and retinoic acid (RA), although the direct biogenesis of RA from beta-carotene has been described...

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Identifiers

PMID: 15108365
DOI: 10.1002/jcb.20073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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