Article
SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Jun 2011
Renga Barbara, Mencarelli Andrea, Migliorati Marco, Cipriani Sabrina, D'Amore Claudio, Distrutti Eleonora, Fiorucci Stefano
Abstract excerpt
OBJECTIVE: The regulation of hepatic stellate cells (HSCs) by bacterial lipopolysaccharide (LPS) represents a recently-discovered and novel mechanism for hepatic injury and fibrosis. Stimulation of HSCs with LPS results in a rapid and marked induction of interleukin (IL)1β, IL6 and tumor necrosis factor α. These events lead to the development of the activated phenotype in the HSCs associated with fibrosis and...
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