Article
Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: the Multiethnic Cohort study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2012
Ollberding Nicholas J, Cheng Iona, Wilkens Lynne R, Henderson Brian E, Pollak Michael N, Kolonel Laurence N, Le Marchand Loïc
Abstract excerpt
BACKGROUND: Increased exposure of colonic and rectal epithelial cells to the promitotic and antiapoptotic effects of insulin and insulin-like growth factors (IGF) is hypothesized to increase colorectal cancer risk. METHODS: In a case-control study nested within the Multiethnic Cohort, we attempted to replicate associations for five genetic variants associated with IGF system biomarkers, insulin, or glucose and to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.