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Article

Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer.

Mutation research - 20 Mar 2006

Samowitz Wade S, Wolff Roger K, Ma Khe Ni, Andersen Kristen, Caan Bette, Slattery Martha L

Abstract excerpt

Risk factors for colon cancer may not only influence the overall risk of cancer but also the risk for specific types of mutations. We evaluated the effect of polymorphisms in four insulin-related genes (G972R in IRS1, G1057D in IRS2, a CA repeat in IGFI and an A/C polymorphism at -202 of IGFBP3) on the risk of microsatellite instability and KRAS2 and TP53 mutations in a population-based set of 1788 cases of colon...

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Source

Identifiers

PMID: 16448675
DOI: 10.1016/j.mrfmmm.2005.10.014

Genes

IRS1
IRS2
IGF1
IGFBP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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