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Article

Insulin receptor variants and obesity-related cancers in the Framingham Heart Study.

Cancer causes & control : CCC - 1 Aug 2015

Parekh Niyati, Guffanti Guia, Lin Yong, Ochs-Balcom Heather M, Makarem Nour, Hayes Richard

Abstract excerpt

PURPOSE: The insulin-signaling pathway plays a pivotal role in cancer biology; however, evidence of genetic alterations in human studies is limited. This case-control study nested within the Framingham Heart Study (FHS) examined the association between inherited genetic variation in the insulin receptor (INSR) gene and obesity-related cancer risk. METHODS: The study sample consisted of 1,475 controls and 396...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26077721
DOI: 10.1007/s10552-015-0613-5
PMCID: PMC7224353

Genes

INSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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