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Article

Caenorhabditis elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing.

Molecular biology of the cell - 1 Dec 2007

Jantsch Verena, Tang Lois, Pasierbek Pawel, Penkner Alexandra, Nayak Sudhir, Baudrimont Antoine, Schedl Tim, Gartner Anton, Loidl Josef

Abstract excerpt

A novel gene, prom-1, was isolated in a screen for Caenorhabditis elegans mutants with increased apoptosis in the germline. prom-1 encodes an F-box protein with limited homology to the putative human tumor suppressor FBXO47. Mutations in the prom-1 locus cause a strong reduction in bivalent formation, which results in increased embryonic lethality and a Him phenotype. Furthermore, retarded and asynchronous...

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Identifiers

PMID: 17914060
DOI: 10.1091/mbc.e07-03-0243
PMCID: PMC2096575

Genes

FBXO47

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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