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Article

Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans.

Nature cell biology - 1 Dec 1999

Kitagawa R, Rose A M

Abstract excerpt

The spindle-assembly checkpoint ensures that, during mitosis and meiosis, chromosomes do not segregate until they are properly attached to the microtubules of the spindle. Here we show that mdf-1 and mdf-2 are components of the spindle-assembly checkpoint in Caenorhabditis elegans, and are essential for the long-term survival and fertility of this organism. Loss of function of either of these genes leads to the...

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PMID: 10587648
DOI: 10.1038/70309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans.PMID 10587648Read ↗

A spindle checkpoint functions during mitosis in the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

Spindle assembly checkpoint genes reveal distinct as well as overlapping expression that implicates MDF-2/Mad2 in postembryonic seam cell proliferation in Caenorhabditis elegans.Semantic proximity Read ↗

Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans.Semantic proximity Read ↗

Active maintenance of meiosis-specific chromosome structures in Caenorhabditis elegans by the deubiquitinase DUO-1.Semantic proximity Read ↗

Components of the spindle assembly checkpoint regulate the anaphase-promoting complex during meiosis in Caenorhabditis elegans.Semantic proximity Read ↗

Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans.Semantic proximity Read ↗

Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle component.Semantic proximity Read ↗

Spindle assembly checkpoint strength is linked to cell fate in theCaenorhabditis elegansembryoSemantic proximity Read ↗

A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegans.Semantic proximity Read ↗

Mutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegans.Semantic proximity Read ↗

The Cdc20 homolog, FZY-1, and its interacting protein, IFY-1, are required for proper chromosome segregation in Caenorhabditis elegans.Semantic proximity Read ↗

MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells.Semantic proximity Read ↗

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