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Article

Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo.

Development (Cambridge, England) - 1 Nov 2007

Oki Shinya, Hashimoto Ryuju, Okui Yuko, Shen Michael M, Mekada Eisuke, Otani Hiroki, Saijoh Yukio, Hamada Hiroshi

Abstract excerpt

Situs-specific organogenesis in the mouse results from leftward fluid flow in the node cavity and subsequent left-sided expression of Nodal in the lateral plate mesoderm (LPM). Nodal expression at the node is essential for the subsequent asymmetric Nodal expression in the left LPM, but the precise role of Nodal produced at the node has remained unknown. We have now investigated how the Nodal signal is transferred...

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Source

Identifiers

PMID: 17913787
DOI: 10.1242/dev.009464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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