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Article

E2F-Dependent Induction of p14ARF During Cell Cycle Re-entry in Human T Cells

1 Nov 2007

Abstract excerpt

The ARF protein, encoded by alternate exon usage within the CDKN2A locus, provides a link between the retinoblastoma (pRb) and p53 tumor suppressor pathways. Agents that disable pRb or otherwise impinge on the E2F family of transcription factors induce expression of ARF, resulting in stabilization of p53 and activation of p53-regulated genes. However, in some cell types ARF is not induced upon cell cycle...

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PMID: 17912037
DOI: 10.4161/cc.6.21.4857

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