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Article

Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc.

The Journal of biological chemistry - 27 Aug 2004

Datta Abhishek, Nag Alo, Pan Wei, Hay Nissim, Gartel Andrei L, Colamonici Oscar, Mori Yasuji, Raychaudhuri Pradip

Abstract excerpt

The tumor suppressor protein ARF (alternate reading frame) inhibits MDM2 to stabilize and activate the functions of p53. Here we provide evidence for an additional activity of ARF that attenuates cell cycle progression independently of p53 activation. We show that ARF interacts with c-Myc independently of MDM2 or p53. Consequently, ARF relocalizes c-Myc from the nucleoplasm to the nucleolus. Binding and...

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Source

Identifiers

PMID: 15199070
DOI: 10.1074/jbc.M312305200

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc.PMID 15199070Read ↗

The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.Semantic proximity Read ↗

Post-Translational Regulation of ARF: Perspective in CancerSemantic proximity Read ↗

The Myc-Nucleophosmin-ARF network: A complex web unveiledSemantic proximity Read ↗

Non-Canonical Functions of the ARF Tumor Suppressor in Development and TumorigenesisSemantic proximity Read ↗

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.Semantic proximity Read ↗

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.Semantic proximity Read ↗

The alternative reading frame tumor suppressor inhibits growth through p21-dependent and p21-independent pathways.Semantic proximity Read ↗

E2F-Dependent Induction of p14ARF During Cell Cycle Re-entry in Human T CellsSemantic proximity Read ↗

Inhibition of p63 transcriptional activity by p14ARF: functional and physical link between human ARF tumor suppressor and a member of the p53 family.Semantic proximity Read ↗

Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2.Semantic proximity Read ↗

A Novel Nuclear Interactor of ARF and MDM2 (NIAM) That Maintains Chromosomal StabilitySemantic proximity Read ↗

Dual Role of the Alternative Reading Frame ARF Protein in CancerSemantic proximity Read ↗

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