Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-21 Promotes Lupus-like Disease in Chronic Graft-versus-Host Disease through Both CD4 T Cell- and B Cell-Intrinsic Mechanisms

21 Jun 2012

Abstract excerpt

T cell-driven B cell hyperactivity plays an essential role in driving autoimmune disease development in systemic lupus erythematosus. IL-21 is a member of the type I cytokine family with pleiotropic activities. It regulates B cell differentiation and function, promotes T follicular helper (T(FH)) cell and Th17 cell differentiation, and downregulates the induction of T regulatory cells. Although IL-21 has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to Immunotherapy and Immune Responses
Share to Systemic Lupus Erythematosus Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22723520
DOI: 10.4049/jimmunol.1200318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-21 Promotes Lupus-like Disease in Chronic Graft-versus-Host Disease through Both CD4 T Cell- and B Cell-Intrinsic MechanismsPMID 22723520Read ↗

Disruption of Pathogenic Cellular Networks by IL-21 Blockade Leads to Disease Amelioration in Murine LupusSemantic proximity Read ↗

Treatment of BXSB‐<i>Yaa</i> Mice with IL‐21R‐Fc Fusion Protein Minimally Attenuates Systemic Lupus ErythematosusSemantic proximity Read ↗

IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cellsSemantic proximity Read ↗

Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice.Semantic proximity Read ↗

MicroRNA-21 deficiency protects from lupus-like autoimmunity in the chronic graft-versus-host disease model of systemic lupus erythematosusSemantic proximity Read ↗

LncRNA IL21‐AS1 interacts with hnRNPU protein to promote IL21 overexpression and aberrant differentiation of Tfh cells in systemic lupus erythematosusSemantic proximity Read ↗

IL-21 Signaling in ImmunitySemantic proximity Read ↗

Decreased serum level of IL-21 in new-onset systemic lupus erythematosus patients.Semantic proximity Read ↗

Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice.Semantic proximity Read ↗

A polymorphism within IL21R confers risk for systemic lupus erythematosus.Semantic proximity Read ↗

Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency.Semantic proximity Read ↗

Elevated frequencies of CD4(+) IL-21(+) T, CD4(+) IL-21R(+) T and IL-21(+) Th17 cells, and increased levels of IL-21 in bleomycin-induced mice may be associated with dermal and pulmonary inflammation and fibrosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.