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Article

Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence.

Addiction biology - 1 Mar 2008

Xuei Xiaoling, Flury-Wetherill Leah, Almasy Laura, Bierut Laura, Tischfield Jay, Schuckit Marc, Nurnberger John I, Foroud Tatiana, Edenberg Howard J

Abstract excerpt

Recent studies in animal models have shown that the nociceptin system, comprising nociceptin (or OFQ/N, encoded by PNOC) and the nociceptin receptor (an opioid receptor-like protein encoded by OPRL1), may be involved in alcohol and other drug reward pathways. To determine whether the nociceptin system is associated with alcohol or illicit drug dependence in humans, we analyzed 10 single nucleotide polymorphisms...

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Source

Identifiers

PMID: 17910740
DOI: 10.1111/j.1369-1600.2007.00082.x

Genes

PNOC
OPRL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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