Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence.

Journal of human genetics - 1 Oct 2012

Zhang Huiping, Herman Aryeh I, Kranzler Henry R, Anton Raymond F, Simen Arthur A, Gelernter Joel

Abstract excerpt

The μ-opioid receptor mediates rewarding effects of alcohol and illicit drugs. We hypothesized that altered DNA methylation in the μ-opioid receptor gene (OPRM1) might influence the vulnerability to alcohol dependence (AD). Genomic DNA was extracted from the peripheral blood of 125 European Americans with AD and 69 screened European American controls. Methylation levels of 16 CpGs in the OPRM1 promoter region...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism
Share to Cocaine-Related Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comorbidity

Share to CpG Islands

Share to DNA Methylation

Share to Marijuana Abuse

Share to Multivariate Analysis

Share to Receptors, Opioid, mu

Source

Open in PubMed Open full text

Identifiers

PMID: 22914673
DOI: 10.1038/jhg.2012.98
PMCID: PMC3481015

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence.PMID 22914673Read ↗

Elevated levels of DNA methylation at the OPRM1 promoter region in men with opioid use disorder.Semantic proximity Read ↗

Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans.Semantic proximity Read ↗

Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence.Semantic proximity Read ↗

Opioid Exposure is Associated with Aberrant DNA Methylation of OPRM1 Promoter Region in a Chinese Han Population.Semantic proximity Read ↗

Methylation and expression quantitative trait loci rs1799971 in the OPRM1 gene and rs4654327 in the OPRD1 gene are associated with opioid use disorder.Semantic proximity Read ↗

Elevated levels of DNA methylation at the OPRM1 promoter in blood and sperm from male opioid addicts.Semantic proximity Read ↗

Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes.Semantic proximity Read ↗

A DNA methylation biomarker of alcohol consumptionSemantic proximity Read ↗

A DNA methylation biomarker of alcohol consumptionSemantic proximity Read ↗

Polymorphisms in the mu-opioid receptor gene (OPRM1) and the implications for alcohol dependence in humans.Semantic proximity Read ↗

Initial evidence of an association between OPRM1 and adolescent alcohol misuse.Semantic proximity Read ↗

Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.